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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 4
1999 3
2000 3
2001 4
2002 2
2003 5
2004 2
2005 3
2006 6
2007 5
2008 2
2009 5
2010 3
2011 10
2012 11
2013 8
2014 13
2015 17
2016 11
2017 11
2018 13
2019 16
2020 20
2021 25
2022 18
2023 26
2024 11

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235 results

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Page 1
Sublethal necroptosis signaling promotes inflammation and liver cancer.
Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T. Vucur M, et al. Immunity. 2023 Jul 11;56(7):1578-1595.e8. doi: 10.1016/j.immuni.2023.05.017. Epub 2023 Jun 16. Immunity. 2023. PMID: 37329888 Free article.
Concomitant necrosome and NF-kappaB activation in hepatocytes, which physiologically express low concentrations of receptor-interacting kinase 3 (RIPK3), did not lead to immediate cell death but forced them into a prolonged "sublethal" state with leaky membranes, functioning as s …
Concomitant necrosome and NF-kappaB activation in hepatocytes, which physiologically express low concentrations of receptor-interacting kina …
The CCL20-CCR6 Axis in Cancer Progression.
Kadomoto S, Izumi K, Mizokami A. Kadomoto S, et al. Int J Mol Sci. 2020 Jul 22;21(15):5186. doi: 10.3390/ijms21155186. Int J Mol Sci. 2020. PMID: 32707869 Free PMC article. Review.
Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are mediators deeply involved in leukocyte migration during an inflammatory reaction. Chemokine (C-C motif) ligand 20 (CCL20), also known as m …
Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are media …
Chemokines in colon cancer progression.
Jia SN, Han YB, Yang R, Yang ZC. Jia SN, et al. Semin Cancer Biol. 2022 Nov;86(Pt 3):400-407. doi: 10.1016/j.semcancer.2022.02.007. Epub 2022 Feb 7. Semin Cancer Biol. 2022. PMID: 35183412 Review.
We focus on CCL20 and its receptor CCR6 as promising factors that affect multiple levels of colon cancer progression. ...Signaling involving CCL20-CCR6 has profound effect on colon cancer hepatic metastasis. ...
We focus on CCL20 and its receptor CCR6 as promising factors that affect multiple levels of colon cancer progression. ...Signaling in …
Highly-metastatic colorectal cancer cell released miR-181a-5p-rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment.
Zhao S, Mi Y, Zheng B, Wei P, Gu Y, Zhang Z, Xu Y, Cai S, Li X, Li D. Zhao S, et al. J Extracell Vesicles. 2022 Jan;11(1):e12186. doi: 10.1002/jev2.12186. J Extracell Vesicles. 2022. PMID: 35041299 Free PMC article.
Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC-related mortality, and is typically caused by interactions between CRC cells and the tumour microenvironment (TME) in the liver. ...These results provide novel insight into the mechanism un …
Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC-related mortality, and is typically caused by interactio …
CCL20 and CD8A as potential diagnostic biomarkers for HBV-induced liver fibrosis in chronic hepatitis B.
Song J, Liu L, Wang Z, Xie D, Azami NLB, Lu L, Huang Y, Ye W, Zhang Q, Sun M. Song J, et al. Heliyon. 2024 Mar 25;10(7):e28329. doi: 10.1016/j.heliyon.2024.e28329. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38596115 Free PMC article.
BACKGROUND: The main cause of the liver fibrosis (LF) remains hepatitis B virus (HBV) infection, especially in China. ...CONCLUSION: CCL20 and CD8A were found to be potential biomarkers and therapeutic targets for HBV-LF. ...
BACKGROUND: The main cause of the liver fibrosis (LF) remains hepatitis B virus (HBV) infection, especially in China. ...CONCLUSION: …
Key genes associated with non-alcoholic fatty liver disease and hepatocellular carcinoma with metabolic risk factors.
Yang F, Ni B, Lian Q, Qiu X, He Y, Zhang Q, Zou X, He F, Chen W. Yang F, et al. Front Genet. 2023 Mar 6;14:1066410. doi: 10.3389/fgene.2023.1066410. eCollection 2023. Front Genet. 2023. PMID: 36950134 Free PMC article.
In recent years, this risk factor has become increasingly recognized as a contributing factor to HCC. Around the world, non-alcoholic fatty liver disease (NAFLD) is on the rise, especially in western countries. ...Conclusion: As a result of the findings of this study, ther …
In recent years, this risk factor has become increasingly recognized as a contributing factor to HCC. Around the world, non-alcoholic fatty …
ALKBH5-mediated m(6) A demethylation of TIRAP mRNA promotes radiation-induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma.
Chen Y, Zhou P, Deng Y, Cai X, Sun M, Sun Y, Wu D. Chen Y, et al. Clin Transl Med. 2023 Feb;13(2):e1198. doi: 10.1002/ctm2.1198. Clin Transl Med. 2023. PMID: 36792369 Free PMC article.
BACKGROUND: Radiation-induced hepatic stellate cell (HSC) activation promotes radiation-induced liver fibrosis (RILF), a complication for hepatocellular carcinoma (HCC) radiotherapy. ...ALKBH5 knockdown-combined CCR6 (CCL20 receptor) inhibitor significantly alleviat …
BACKGROUND: Radiation-induced hepatic stellate cell (HSC) activation promotes radiation-induced liver fibrosis (RILF), a complication …
CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis.
Affò S, Morales-Ibanez O, Rodrigo-Torres D, Altamirano J, Blaya D, Dapito DH, Millán C, Coll M, Caviglia JM, Arroyo V, Caballería J, Schwabe RF, Ginès P, Bataller R, Sancho-Bru P. Affò S, et al. Gut. 2014 Nov;63(11):1782-92. doi: 10.1136/gutjnl-2013-306098. Epub 2014 Jan 10. Gut. 2014. PMID: 24415562 Free PMC article.
In our study, we hypothesise that chemokine CCL20, one of the most upregulated chemokines in patients with AH, is implicated in the pathogenesis of AH by mediating LPS induced liver injury. ...Moreover, CCL20 expression was increased in animal models of li …
In our study, we hypothesise that chemokine CCL20, one of the most upregulated chemokines in patients with AH, is implicated in the p …
IFNγ-IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human hepatocellular carcinoma.
Lee YH, Chuah S, Nguyen PHD, Lim CJ, Lai HLH, Wasser M, Chua C, Lim TKH, Leow WQ, Loh TJ, Wan WK, Pang YH, Soon G, Cheow PC, Kam JH, Iyer S, Kow A, Bonney GK, Chan CY, Chung A, Goh BKP, Zhai W, Chow PKH, Albani S, Liu H, Chew V. Lee YH, et al. Cancer Lett. 2023 Jan 1;552:215977. doi: 10.1016/j.canlet.2022.215977. Epub 2022 Oct 21. Cancer Lett. 2023. PMID: 36279983 Free article.
In particular, we discovered that IFNgamma(-) Tc17 subset demonstrated pro-tumoral characteristics and expressed higher levels of CCL20. This corresponded to increased tumor infiltration of T regulatory cells (Treg) validated by immunohistochemistry in another independent …
In particular, we discovered that IFNgamma(-) Tc17 subset demonstrated pro-tumoral characteristics and expressed higher levels of CCL20 …
CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading.
Chu X, Jin Q, Chen H, Wood GC, Petrick A, Strodel W, Gabrielsen J, Benotti P, Mirshahi T, Carey DJ, Still CD, DiStefano JK, Gerhard GS. Chu X, et al. J Transl Med. 2018 Apr 24;16(1):108. doi: 10.1186/s12967-018-1490-y. J Transl Med. 2018. PMID: 29690903 Free PMC article.
Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. ...CCL20 serves as a chemoattractant molecule for immature dendritic cells, which have been shown to produce many of the inflammatory molecules that mediate liver fib …
Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. ...CCL20 serves as a chemoattract …
235 results